Members

Tadahiro Shimazu

Tadahiro Shimazu, Ph.D

ResearchMap:
  • https://researchmap.jp/tadahiro_shimazu
  • Education

    1998-2002
    Faculty of Agriculture, The University of Tokyo, Japan, B. S., 2002
    2002-2007
    Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan. Ph. D., 2007

    Research and Professional Experience

    2007-2011
    Postdoctoral Fellow, University of California, San Francisco, U.S.A.
    2011
    Postdoctoral Researcher, RIKEN, Japan
    2011- 2016
    Staff Scientist, RIKEN, Japan
    2016- present
    Senior Research Scientist, RIKEN, Japan

    Awards and Professional Activities

    2020
    JSPS GIA for Scientific Research (C)
    2016
    Inamori Grant Program, JSPS GIA for YS-B
    2015
    Takeda Science Foundation, The Naito Foundation, The Uehara Memorial Foundation, The Mochida Memorial Foundation for Medical and Pharmaceutical Research
    2012
    Fund for Seeds of Collaborative Research, RIKEN
    2004-
    Member, The Molecular Biology Society of Japan
    2015-
    Member, The Japanese Society for Epigenetics

    Publication List

    1. Shimazu T#*. Yoshimoto R#. Kotoshiba K. Suzuki T. Matoba S. Hirose M. Akakabe M. Sohtome Y. Sodeoka M. Ogura A. Dohmae N. Shinkai Y*. Histidine N1-position-specific methyltransferase CARNMT1 targets C3H zinc finger proteins and modulates RNA metabolism. Genes & Development. 2023 Aug 23. doi: 10.1101/gad.350755.123. [PubMed]
    2. Matsuura-Suzuki E#. Shimazu T#*. Takahashi M. Kotoshiba K. Suzuki T. Kashiwagi K. Dohmae N. Ito T*. Shinkai Y*. Iwasaki S*. METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance. eLife 2022 Jun 8;11:e72780. doi: 10.7554/eLife.72780. [PubMed]
    3. Sohtome Y*. Shimazu T*. Shinkai Y*. Sodeoka M*. Propargylic Se-adenosyl-l-selenomethionine: A Chemical Tool for Methylome Analysis. Acc Chem Res.2021 Oct 19;54(20):3818-3827. [PubMed]
    4. Davydova E#. Shimazu T#. Schuhmacher M.K. Jakobsson M.E. Willemen H.L.D.M. Liu T. Moen A. Ho A.Y.Y. Małecki J. Schroer L. Pinto R. Suzuki T. Gronsberg I.A. Sohtome Y. Akabane M. Weirich S. Kikuchi M. Olsen J.V. Dohmae N. Umehara T. Sodeoka M. Siino V. McDonough M. Eijkelkamp N. Schofield C.J. Jeltsch A*. Shinkai Y*. Falnes P.O*. The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes. Nat Commun. 2021, 12:891. [PubMed]
    5. Tsusaka T, Shimura C, Shinkai Y*. ATF7IP regulates SETDB1 nuclear localization and increases its ubiquitination. EMBO reports. [PubMed]
    6. Sohtome, Y., Shimazu, T., Barjau, J., Fujishiro, S., Akakabe, M., Terayama, N., Dodo, K., Ito, A., Yoshida, M., Shinkai, Y., and Sodeoka, M. (2018). Unveiling epidithiodiketopiperazine as a non-histone arginine methyltransferase inhibitor by chemical protein methylome analyses. Chem Commun (Camb), 54(66): 9202-9205. PMID: 30063235 [PubMed]
    7. Shimazu T, Furuse T, Balan S, Yamada I, Okuno S, Iwanari H, Suzuki T, Hamakubo T, Dohmae N, Yoshikawa T, Wakana S, Shinkai Y*. Role of METTL20 in regulating β-oxidation and heat production in mice under fasting or ketogenic conditions.Sci Rep. 2018 Jan 19;8(1):1179 [PubMed]
    8. Ferry L#, Fournier A#, Tsusaka T#, Adelmant G, Shimazu T, Matano S, Kirsh O, Amouroux R, Dohmae N, Suzuki T, Filion GJ, Deng W, de Dieuleveult M, Fritsch L, Kudithipudi S, Jeltsch A, Leonhardt H, Hajkova P, Marto JA, Arita K, Shinkai Y*, Defossez PA*. Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation. Mol Cell. 2017 Aug 17;67(4):550-565.e5. #These authors contributed equally [PubMed]
    9. Shirakawa, K., Wang, L., Man, N., Maksimoska, J., Sorum, A. W., Lim, H. W., Lee, I. S., Shimazu, T., Newman, J. C., Schroder, S., Ott, M., Marmorstein, R., Meier, J., Nimer, S., and Verdin, E. (2016). Salicylate, diflunisal and their metabolites inhibit CBP/p300 and exhibit anticancer activity. Elife, 5: e11156. PMID: 27244239 26602019
    10. Shimazu, T. Barjau, J. Sohtome, Y. Sodeoka, M. and Shinkai, Y. Selenium-based S-adenosylmethionine analog reveals the mammalian seven-beta-strand methyltransferase METTL10 to be an EF1A1 lysine methyltransferase. PLOS ONE 2014 Aug 21;9(8):e105394. doi: 10.1371/journal.pone.0105394.[PubMed]
    11. Shimazu, T., M.D. Hirschey, J. Newman, W. He, K. Shirakawa, N. Le Moan, C.A. Grueter, H. Lim, L.R. Saunders, R.D. Stevens, C.B. Newgard, R.V. Farese, Jr., R. de Cabo, S. Ulrich, K. Akassoglou, and E. Verdin (2013). Suppression of oxidative stress by beta-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science. 339:211-4. PMID: 23223453
    12. Takahashi, M., Y. Takemoto, T. Shimazu, H. Kawasaki, M. Tachibana, Y. Shinkai, M. Takagi, K. Shin-ya, Y. Igarashi, A. Ito, and M. Yoshida (2012). Inhibition of histone H3K9 methyltransferases by gliotoxin and related epipolythiodioxopiperazines. J Antibiot (Tokyo). 65:263-5. PMID: 22334240
    13. Cho, H.S., T. Shimazu, G. Toyokawa, Y. Daigo, Y. Maehara, S. Hayami, A. Ito, K. Masuda, N. Ikawa, H.I. Field, E. Tsuchiya, S. Ohnuma, B.A. Ponder, M. Yoshida, Y. Nakamura, and R. Hamamoto (2012). Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B. Nat Commun. 3:1072. PMID: 22990868
    14. Hirschey, M.D., T. Shimazu, E. Jing, C.A. Grueter, A.M. Collins, B. Aouizerat, A. Stancakova, E. Goetzman, M.M. Lam, B. Schwer, R.D. Stevens, M.J. Muehlbauer, S. Kakar, N.M. Bass, J. Kuusisto, M. Laakso, F.W. Alt, C.B. Newgard, R.V. Farese, Jr., C.R. Kahn, and E. Verdin (2011). SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell. 44:177-90. PMID: 21856199
    15. Hirschey, M.D., T. Shimazu, J.A. Capra, K.S. Pollard, and E. Verdin (2011). SIRT1 and SIRT3 deacetylate homologous substrates: AceCS1,2 and HMGCS1,2. Aging (Albany NY). 3:635-42. PMID: 21701047
    16. Shimazu, T., M.D. Hirschey, J.Y. Huang, L.T. Ho, and E. Verdin (2010). Acetate metabolism and aging: An emerging connection. Mech Ageing Dev. 131:511-6. PMID: 20478325
    17. Shimazu, T., M.D. Hirschey, L. Hua, K.E. Dittenhafer-Reed, B. Schwer, D.B. Lombard, Y. Li, J. Bunkenborg, F.W. Alt, J.M. Denu, M.P. Jacobson, and E. Verdin (2010). SIRT3 deacetylates mitochondrial 3-hydroxy-3-methylglutaryl CoA synthase 2 and regulates ketone body production. Cell Metab. 12:654-61. PMID: 21109197
    18. Huang, J.Y., M.D. Hirschey, T. Shimazu, L. Ho, and E. Verdin (2010). Mitochondrial sirtuins. Biochim Biophys Acta. 1804:1645-51. PMID: 20060508
    19. Hirschey, M.D., T. Shimazu, E. Goetzman, E. Jing, B. Schwer, D.B. Lombard, C.A. Grueter, C. Harris, S. Biddinger, O.R. Ilkayeva, R.D. Stevens, Y. Li, A.K. Saha, N.B. Ruderman, J.R. Bain, C.B. Newgard, R.V. Farese, Jr., F.W. Alt, C.R. Kahn, and E. Verdin (2010). SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 464:121-5. PMID: 20203611
    20. Hirschey, M.D., T. Shimazu, J.Y. Huang, and E. Verdin (2009). Acetylation of mitochondrial proteins. Methods Enzymol. 457:137-47. PMID: 19426866
    21. Kamemura, K., A. Ito, T. Shimazu, A. Matsuyama, S. Maeda, T.P. Yao, S. Horinouchi, S. Khochbin, and M. Yoshida (2008). Effects of downregulated HDAC6 expression on the proliferation of lung cancer cells. Biochem Biophys Res Commun. 374:84-9. PMID: 18602369
    22. Shimazu, T., S. Horinouchi, and M. Yoshida (2007). Multiple histone deacetylases and the CREB-binding protein regulate pre-mRNA 3'-end processing. J Biol Chem. 282:4470-8. PMID: 17172643
    23. Tomono, A., M. Mashiko, T. Shimazu, H. Inoue, H. Nagasawa, M. Yoshida, Y. Ohnishi, and S. Horinouchi (2006). Self-activation of serine/threonine kinase AfsK on autophosphorylation at threonine-168. J Antibiot (Tokyo). 59:117-23. PMID: 16629414
    24. Shimazu, T., Y. Komatsu, K.I. Nakayama, H. Fukazawa, S. Horinouchi, and M. Yoshida (2006). Regulation of SV40 large T-antigen stability by reversible acetylation. Oncogene. 25:7391-400. PMID: 16767160
    25. Masumi, A., H. Fukazawa, T. Shimazu, M. Yoshida, K. Ozato, K. Komuro, and K. Yamaguchi (2006). Nucleolin is involved in interferon regulatory factor-2-dependent transcriptional activation. Oncogene. 25:5113-24. PMID: 16582966
    26. Yoshida, M., T. Shimazu, and A. Matsuyama (2003). Protein deacetylases: enzymes with functional diversity as novel therapeutic targets. Prog Cell Cycle Res. 5:269-78. PMID: 14593721
    27. Matsuyama, A., T. Shimazu, Y. Sumida, A. Saito, Y. Yoshimatsu, D. Seigneurin-Berny, H. Osada, Y. Komatsu, N. Nishino, S. Khochbin, S. Horinouchi, and M. Yoshida (2002). In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation. EMBO J. 21:6820-31. PMID: 12486003

    Members

    page top